Running title: Association between ERG and Androgen Receptor Key words: TMPRSS2-ERG, Androgen Receptor, Prognosis, Tissue Microarray (TMA), Prostate Cancer
نویسندگان
چکیده
Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany Unit Cancer Genome Research, Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany Department of Urology, University of Washington, Seattle, USA Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf, Germany Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Germany Department of Anatomy II, University Medical Center Hamburg-Eppendorf, Germany Department of Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Germany Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Germany
منابع مشابه
TITLE: Evaluation of Androgen Receptor Function in Prostate Cancer Prognosis and Therapeutic Stratification PRINCIPAL INVESTIGATOR:
half of all prostate cancers in the Western countries harbor gene fusions that involve regulatory sequences of the androgen receptor (AR)-responsive genes (predominantly TMPRSS2) and protein coding sequences of nuclear transcription factors of the ETS gene family (predominantly ERG). This leads to unscheduled androgen-dependent expression ofETS-related transcription factors in tumor cell-specif...
متن کاملERG/AKR1C3/AR Constitutes a Feed-Forward Loop for AR Signaling in Prostate Cancer Cells.
PURPOSE Intratumoral androgen synthesis in prostate cancer contributes to the development of castration-resistant prostate cancer (CRPC). Several enzymes responsible for androgen biosynthesis have been shown to be overexpressed in CRPC, thus contributing to CRPC in a castrated environment. The TMPRSS2-ERG transcription factor has been shown to be present in primary prostate cancer tumors as wel...
متن کاملOverexpression of prostate-specific TMPRSS2(exon 0)-ERG fusion transcripts corresponds with favorable prognosis of prostate cancer.
PURPOSE To gain insight in the mechanism and clinical relevance of TMPRSS2-ERG expression in prostate cancer, we determined the specific characteristics of fusion transcripts starting at TMPRSS2 exon 1 and at a more upstream and less characterized exon 0. EXPERIMENTAL DESIGN We used quantitative PCR analysis to investigate expression of wild-type TMPRSS2(exon 0) and TMPRSS2(exon 1) and of ERG...
متن کاملERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.
Fusion of the androgen receptor-regulated (AR-regulated) TMPRSS2 gene with ERG in prostate cancer (PCa) causes androgen-stimulated overexpression of ERG, an ETS transcription factor, but critical downstream effectors of ERG-mediating PCa development remain to be established. Expression of the SOX9 transcription factor correlated with TMPRSS2:ERG fusion in 3 independent PCa cohorts, and ERG-depe...
متن کاملAndrogen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells.
Fusion genes play important roles in tumorigenesis. The identification of the high-frequency TMPRSS2 fusion with ERG and other ETS family genes in prostate cancer highlights the importance of fusion genes in solid tumor development and progression. However, the mechanisms leading to these fusions are unclear. We investigated whether androgen, through stimulating its receptor, could promote spat...
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تاریخ انتشار 2011